| Rates of youth depression have been rising in recent years, and present substantial negative impacts to individual children, their families, and society at large. However, compared to other diagnostic domains, youth psychosocial treatments have traditionally demonstrated relatively poor efficacy in treating childhood depression. Recent research has shown the potential of Parent-Child Interaction Therapy (PCIT) and several diagnostically adapted PCIT protocols to treat broad internalizing problems and anxiety-related disorders. Yet, there is comparatively limited research on PCIT’s efficacy for youth depression. Thus, the present systematic review and meta-analysis used best practice Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) methodology, paralleling Phillips and Mychailyszyn’s (2021) systematic review and meta-analysis of PCIT for youth anxiety. Specifically, four databases (i.e., PsycINFO, PubMed, CINAHL, and Web of Science) with established keywords were used, generating 101 non-redundant records for screening by independent coders. Additionally, 977 records were identified using other methods (e.g., experts in the field, backward and forward citation searches), for a total of 1,078 records assessed for inclusion in the final review. Based upon this study’s eligibility criteria and full-text coding, nine articles met inclusion criteria for the present review, with 534 total children (ages 2–12) participating in included studies. The present study systematically reviewed the findings from these studies, including reporting of descriptive statistics from these studies. The present study also calculated PCIT’s meta-analytic pre- to post-treatment effect on child depressive symptoms across these studies (g = -1.18), its metaanalytic efficacy compared to controls (gdiff = 0.72), and the degree to which effect size varied significantly across (1) standard or adapted protocols and/or (2) samples with clinical versus subclinical depression. Keywords: Parent-Child Interaction Therapy, PCIT, PCIT-ED, youth depression |