| This research investigated the performance of the published Pu-DTPA biokinetic model
(Konzen and Brey 2015) applied to cases involving an americium uptake influenced by DTPA treatment. Transfer rates for the Am-DTPA complex were developed from the IDEAS Case 32 urine bioassay data in an attempt to model americium metabolism under the influence of DTPA treatment. The fit of the urine data was assessed using the logarithmic chi-squared value and autocorrelation statistic, with the intake estimated using the maximum likelihood method. The Am-DTPA model provided a better fit of the Case 32 urine data than published models. The Am-DTPA model was next applied to the USTUR Case 0856 urine data and resulted in a poor fit. While not a statistically significant result, the Am-DTPA model resulted in an improved bioassay prediction, compared to reference models and suggested Pu-DTPA rates, when assessing chelation influenced urine bioassay data. Key Words: americium, chelation, biokinetic |