| Synthetic flaxseed lignan LGM2605 is noted for its antioxidant and anti-inflammatory properties. Previously,oral administration ofLGM2605 was shown to reduce early(3-day)immune responsesresulting from acute exposure to Libby amphibole (LA) asbestos; however, its effects on later (adaptive) immune responses have not yet been evaluated. Furthermore, no previous work has investigated the effects of orally administered LGM2605 on gut microbial composition.Through our research, we expanded upon the previous work by evaluating the effects of LGM2605 treatmentwithin a 14-day murine model of asbestos exposure. We found that LGM2605reducedinflammation as well as both innate and adaptiveimmuneresponses in LA-exposed mice at 14 days,supporting its possible use in the preventionof LA-induceddiseases.We alsoconsidered the effects of 10-day LGM2605treatment on gut microbiota of mice. We identified alterations in gut microbiota following LGM2605treatment,in general shifting towards a more anti-inflammatory microbial composition. Key words: asbestos; autoimmunity; dysbiosis; flaxseed; gut microbiota;LGM2605; Libby amphibole; secoisolarisiresinol diglucoside; systemic inflammation |