| Arsenicpollutionis a global health threatand affects many human populations throughout the world. Arsenic pollution can occur through natural means, andit can also occur as industrial process such as miningwhich canlead to runoff that contaminates soil and drinking water. When ingested, arsenic can cause a variety of negative health effects including skin lesions, cancer, heart disease and diabetes.Bioremediation is a possible method of arsenic removal thatuses bacteria to transform arsenic into a more manageable form.Thermus sp. AO3C is a gram-negative thermophilic bacterium that was isolated from arsenic-containing hot springs in Alvord, Oregon and that has been shown to be capable of arsenic oxidation. Proteogenomic analysis of this organism led to the identification of key enzymes involved in its arsenic resistance and respiration pathways. Through whole genome sequencing and annotation,we identified arsenite oxidase and arsenate reductase enzymes critical in arsenic resistance.Key words:Arsenic resistance, Thermus,Arsenate Reductase, Arsenite Oxidase,Proteomics |